Photothermal therapy (PTT) is one of the most efficient therapies that can induce necrosis of specific malignant lesions with minimal invasiveness and side effects compared with other therapeutic modalities.
In this context, applications are open for a postdoctoral fellowship position funded by the “FireLight” projet-FEDER – Photoactive molecules and nanoparticles.
The position will be based at L2CM (http://www.l2cm.univ-lorraine.fr/l2cm/), CRAN (http://www.cran.univ-lorraine.fr/) and ICL (http://www.icl-lorraine.fr/) laboratories in Nancy (France).
The research program will focus on the development of indocyanine green (ICG) loaded Solid Lipid Nanoparticles (SLN) and on the characterization of photophysical (size and charges measurements, spectral characterization, thermal effect) and photobiological properties (uptake, intracellular fluorescence and localization, therapeutic efficiency). The biological model used will be 2D and 3D cell cultures and animal models.
Selection process: Interested candidates should send a CV, a scientific track record, a motivation letter and two recommendation letters to:
Dr. Henri-Pierre Lassalle / Prof. Andreea Pasc
Contact: email@example.com; firstname.lastname@example.org
Skills/Qualifications: Candidates for this postdoctoral fellowship must hold a PhD degree in cell biology, good knowledge in photobiology will be required, as well as experience in animal experiments (the authorization to experiment on animals will be highly appreciated). Creativity, autonomy and strong reliability are highly required. All applicants must be able to communicate fluently in French and/or English (speaking and writing). The position is available for a period of 18 months, starting from September 2020.
Keywords: Cancer, Nanoparticle, Photothermal therapy (PTT), NIR fluorescence, Indocyanine green, Photodiagnosis.
CRAN - Centre de Recherche en Automatique de Nancy
ICL - Institut de Cancérologie de Lorraine
Université de Lorraine
The aim of the thesis program is to develop photosensitive compounds from low-cost and environmentally friendly metal complexes. While ruthenium complexes have been widely studied and used in many laboratory applications because of their ideal photophysical properties, ruthenium is a rare, toxic and expensive metal, which limits real industrial development. Our project aims to replace this metal with other metals such as iron, which is strategic in the search for low-cost devices and industrial processes that conserve resources. In particular, we are targeting the development of photosensitizers for the manufacture of dye solar cells (DSSCs).
The synthesis of (hetero)aromatic compounds is an omnipresent challenge for the organic chemist due to their multiple and varied applications. Indeed aromatic and heterocycle moieties are everywhere in day life, either in materials science, optics, electronics or biology. Thus, researches in organic synthesis methodologies are continually in progress for the preparation of heterocycles and their functionalization.
That is why, the aim of this PhD project is to develop original organometallic reagents to allow the development of innovative synthetic sequences for the preparation of highly functionalized (hetero)aromatic derivatives. In particular, we will focus our attention on bimetallic ate complexes as metalating reagents for metal-halogen exchange (MHE) or deprotonation. Their design, preparation and reactivity will be studied at first on heterocycle model and then exemplify to various heterocycles. Bimetallic ate complexes result in combining a polar organometallic (e.g. an organolithium) with a “soft” organometallic (organomagnesium for example), which the behaviour is different from those of the precursor. The principle is a synergy created by mixing two different organometallic reagents allowing increased selectivity and reactivity as well as use under non-cryogenic conditions compared to the monometallic reagent.
more details in the job offer desciption (file attached)