Project AIM +: Anticancer Iron Made+ AIM+ is a multidisplinary project at the interface between chemistry and biology. The aim is to develop a novel type of DNA hypomethylating agents able to bind DNA and to chemically induce its direct demethylation. Based on preliminary results showing a decrease in the 5‐methylcytosine level as well as a strong reduction of cell proliferation, our project aims to achieve the comprehension, at the molecular level, of its action mode. Our final goal is to develop an entire novel class of epigenetic drugs and harness their ability to control cell proliferation for therapeutic purposes. For this, AIM+ project will enhance, via proper chemical modifications, the demethylating activity and the selectivity of the proposed system. AIM+ is based on a multidisciplinary consortium gathering synthesis, molecular modelling and biology. The aim of the postdoctoral fellowship is to synthesise and characterize a range of new hypomethylating agents based on the preliminary results obtained by the consortium.
Université de Lorraine
The aim of the thesis program is to develop photosensitive compounds from low-cost and environmentally friendly metal complexes. While ruthenium complexes have been widely studied and used in many laboratory applications because of their ideal photophysical properties, ruthenium is a rare, toxic and expensive metal, which limits real industrial development. Our project aims to replace this metal with other metals such as iron, which is strategic in the search for low-cost devices and industrial processes that conserve resources. In particular, we are targeting the development of photosensitizers for the manufacture of dye solar cells (DSSCs).
The synthesis of (hetero)aromatic compounds is an omnipresent challenge for the organic chemist due to their multiple and varied applications. Indeed aromatic and heterocycle moieties are everywhere in day life, either in materials science, optics, electronics or biology. Thus, researches in organic synthesis methodologies are continually in progress for the preparation of heterocycles and their functionalization.
That is why, the aim of this PhD project is to develop original organometallic reagents to allow the development of innovative synthetic sequences for the preparation of highly functionalized (hetero)aromatic derivatives. In particular, we will focus our attention on bimetallic ate complexes as metalating reagents for metal-halogen exchange (MHE) or deprotonation. Their design, preparation and reactivity will be studied at first on heterocycle model and then exemplify to various heterocycles. Bimetallic ate complexes result in combining a polar organometallic (e.g. an organolithium) with a “soft” organometallic (organomagnesium for example), which the behaviour is different from those of the precursor. The principle is a synergy created by mixing two different organometallic reagents allowing increased selectivity and reactivity as well as use under non-cryogenic conditions compared to the monometallic reagent.
more details in the job offer desciption (file attached)