One year position from October or November 2019

Post-doctoral in coordination chemistry at the interface with biology

Filled

Project AIM +: Anticancer Iron Made+ AIM+ is a multidisplinary project at the interface between chemistry and biology. The aim is to develop a novel type of DNA hypomethylating agents able to bind DNA and to chemically induce its direct demethylation. Based on preliminary results showing a decrease in the 5‐methylcytosine level as well as a strong reduction of cell proliferation, our project aims to achieve the comprehension, at the molecular level, of its action mode. Our final goal is to develop an entire novel class of epigenetic drugs and harness their ability to control cell proliferation for therapeutic purposes. For this, AIM+ project will enhance, via proper chemical modifications, the demethylating activity and the selectivity of the proposed system. AIM+ is based on a multidisciplinary consortium gathering synthesis, molecular modelling and biology. The aim of the postdoctoral fellowship is to synthesise and characterize a range of new hypomethylating agents based on the preliminary results obtained by the consortium.

Dr Philippe C. Gros (L2CM, UMR 7053) - Contacter
L2CM - Laboratoire Lorraine de Chimie Moléculaire à Nancy
Université de Lorraine

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18 months starting September 2020

Post-doctoral position in cell biology/cancer photobiology

Photothermal therapy (PTT) is one of the most efficient therapies that can induce necrosis of specific malignant lesions with minimal invasiveness and side effects compared with other therapeutic modalities.

In this context, applications are open for a postdoctoral fellowship position funded by the “FireLight” projet-FEDER – Photoactive molecules and nanoparticles.

The position will be based at L2CM (http://www.l2cm.univ-lorraine.fr/l2cm/), CRAN (http://www.cran.univ-lorraine.fr/) and ICL (http://www.icl-lorraine.fr/) laboratories in Nancy (France).

The research program will focus on the development of indocyanine green (ICG) loaded Solid Lipid Nanoparticles (SLN) and on the characterization of photophysical (size and charges measurements, spectral characterization, thermal effect) and photobiological properties (uptake, intracellular fluorescence and localization, therapeutic efficiency). The biological model used will be 2D and 3D cell cultures and animal models.

Selection process: Interested candidates should send a CV, a scientific track record, a motivation letter and two recommendation letters to:

Dr. Henri-Pierre Lassalle / Prof. Andreea Pasc

Contact: henri-pierre.lassalle@univ-lorraine.fr; andreea.pasc@univ-lorraine.fr

Skills/Qualifications: Candidates for this postdoctoral fellowship must hold a PhD degree in cell biology, good knowledge in photobiology will be required, as well as experience in animal experiments (the authorization to experiment on animals will be highly appreciated). Creativity, autonomy and strong reliability are highly required. All applicants must be able to communicate fluently in French and/or English (speaking and writing). The position is available for a period of 18 months, starting from September 2020.

Keywords: Cancer, Nanoparticle, Photothermal therapy (PTT), NIR fluorescence, Indocyanine green, Photodiagnosis.

18 months starting September 2020

Post-doctoral position in organic chemistry/photo-bio-chemistry

Over the last decade, photothermal therapy (PTT) have attracted increasing attention as a potential alternative to classical ones. It involves both molecules or nanoparticles absorbing photons upon NIR irradiation and generating heat through non-radiative relaxation pathways.

In this context, applications are open for a postdoctoral fellowship position funded by the “FireLight” projet-FEDER – Photoactive molecules and nanoparticles. The position will be based at L2CM laboratory in Nancy (France). The research program will focus on the synthesis of calixarene derivatives and the characterization of the optical and photophysical properties of the resulting molecular self-assemblies and calixarene-MoS2 nanoparticles assembled systems. The project will also include photobiochemical characterization triggering anti-bacterial applications.

Skills/Qualifications: Candidates for this postdoctoral fellowship must hold a PhD degree in organic chemistry, preferably with experience in photobiochemistry. Creativity, autonomy and strong reliability are highly required. All applicants must be able to communicate fluently in French and/or English (speaking and writing). The position is available for a period of 18 months, starting from September 2020.

Selection process: Interested candidates should send a CV, a scientific track record, a motivation letter and two recommendation letters to:

Prof. Jean-Bernard Regnouf de Vains / Prof. Andreea Pasc

Contact: jean-bernard.regnouf@univ-lorraine.fr; andreea.pasc@univ-lorraine.fr

Application deadline 15 juin.