Combined [18F]PET/NIRF imaging (Positron Emission Tomography/Near Infra Red Fluorescence) hold a huge potential to transform patient diagnosis and care. Such a combination conjugates the non-invasive whole-body diagnosis of PET with the intraoperative imaging-guided surgery or ex vivo histopathology of NIRF imaging. M3ODALIty will design and synthesize two innovative dual [18F]PET/NIRF imaging dyes in addressing a double chemical and radiochemical challenge. The structure will gather a cyanine derivative and fluorine-18 bound to a carbon center. Based on these dyes, original MOnoMolecular dual Imaging Tools (MOMITs) for combined TEP/NIRF imaging will be elaborated. M3ODALIty ambitions to leverage the imaging options by the use, for the first time, of a bambusuril-scaffold allowing for a multivalent or multiplexed decoration with targeting entities. A proof of concept of these innovative MOMITs will be established in a robust and well validated model of angiogenesis using c(RGDfK) and A7R peptides targeting integrins and Neuropilin-1 receptors, respectively.
|Partner||Organization||Unit (Director)||Team involved in M3ODALIty|
|P1a||CEA||CEA IMIV U1023 (I Buvat)||Molecular Probes (B. Kuhnast, coordinateur, F. Caillé, S. Specklin)|
|P1b||SCBM (F Taran)||Development of new methodologies in organic synthesis (M.P. Heck)|
|P2||Université de Lorraine||UMR7053 (P Gros)||MoLSyBio (S. Lamandé-Langle, N. Pellegrini-Moïse, K. Selmeczi, M. Mourer)|
|P3||CRAN UMR7039 (D Wolf)||Integrative Biology: Cybernetics of radiation therapies BEAM team (T. Bastogne, C. Boura)|